Acute neuroinflammation and neurogenesis: A role for microglial COX-1
نویسندگان
چکیده
منابع مشابه
P 67: The Role of Neuroinflammation in Dysfunction of Adult Hippocampal Neurogenesis
Neuroinflammation as a protective mechanism for repairing tissue damage in the central nervous system (CNS), has been classified into two types: acute and chronic. It is characterized by the activation of microglia and astrocytes and the increase levels of different chemokines and cytokines. Neuroinflammation can be harmful, and it is a common pathological feature in neurodegenerative and psych...
متن کاملCyclooxygenase (COX)-1 expressing macrophages/microglial cells and COX-2 expressing astrocytes accumulate during oligodendroglioma progression.
Cyclooxygenases (COX, prostaglandin endoperoxide synthases, PGG/H synthases) are potent mediators of edema, impeding blood flow and immunomodulation in the pathologically altered brain. Two COX iso-enzymes have been associated with brain disease, the constitutively expressed COX-1 and the cytokine-inducible COX-2. We have used single and double labeling immunohistochemistry to analyse COX-1 and...
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NEW NEURONS ARE CONTINUOUSLY GENERATED IN TWO ADULT BRAIN REGIONS: the subgranular zone of the hippocampus and the subependyma by the lateral ventricles, referred to as the neurogenic niches. During their development from neural stem cells to mature functionally integrated neurons numerous choices are made, such as proliferation or quiescence, cell survival or death, migration or establishment,...
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(AD) is a chronic neuro-degenerative disorder characterized by progressive cognitive decline and memory loss. Accumulation of β-amyloid (Aβ) and tau protein are believed to be important pathological features of AD [1]. Results from a large number of studies suggest that neuro-inflammation is a key contributor to neuronal loss in AD. Anti-inflammatory drugs, in particular non-steroidal anti-infl...
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One of the most serious neurodegenerative disorders is Alzheimer disease (AD). As the population is aging and due to the fact that AD is more common in aged people, more attention must be paid to this disease. One of the main characteristics of AD is dementia which starts with loss of short term memory, then progresses and causes various brain dysfunctions such as loss of long term memory. Inte...
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ژورنال
عنوان ژورنال: Cell Cycle
سال: 2011
ISSN: 1538-4101,1551-4005
DOI: 10.4161/cc.10.22.18193